Creating functional vascular networks that mimic biological complexity is a significant hurdle in the realm of 3D bioprinting. The resolution inherent in 3D printing technology poses a challenge when attempting to replicate the intricate millimeter-scale vascular networks within organs, alongside the overall organ structure. Developing a 3D bioprinter capable of achieving this level of detail is a key technological objective in Printing Organs With 3d Printer. Currently, common methods for printing these crucial vascular networks involve sacrificial bioinks, which are removed after printing, or coaxial bioprinting for direct fabrication of vascular tubes.
Exploring bioink formulations with specific bioactive materials to promote vascularization is a promising direction for future research. Achieving proper organ vascularization, both in vitro and in vivo, necessitates advancements in both 3D bioprinting technology and biomaterial development.
Biotechnological progress will empower researchers with enhanced tools to further investigate biomimetic vascularization techniques for organs.
At CELLINK, we are actively developing both extrusion-based and light-based bioprinting technologies. For implantable organ structures, a combined approach utilizing both technologies appears advantageous. Extrusion-based printing offers versatility and excels in creating the general organ framework. However, achieving the fine details required for a functional vascular system becomes more demanding with extrusion techniques alone. This is where light-based bioprinting proves invaluable. Light-based bioprinting offers superior resolution and eliminates the need for sacrificial bioinks, making it more suitable for printing intricate features like vascular networks. For further insights into combining extrusion and light-based methods, refer to our technical note on the biofabrication of vascularized skin tissue models.
